Responding to global threats
AntoXa Corporation was created in response to growing demand for safe, effective therapeutics for national stockpiles against emerging threats to national security and public health, from weaponized chemical agents and pathogens.
Low-cost proprietary platform
AntoXa’s medical countermeasures are produced using a rapid, low-cost plant-based system that ensures high-quality drug products. With an exclusive license to use PlantForm Corporation’s vivoXPRESS® manufacturing system, AntoXa is able to produce a wide range of biopharmaceuticals in less than six weeks — far quicker than other systems.
A growing product pipeline
AntoXa Corporation is engaged with government and military agencies in Canada, the United States, Australia and Brazil to develop a range of biodefense solutions including:
PhD9 antibody for ricin exposure
AntoXa is developing a PhD9 antibody drug candidate under licence from Defence Research & Development (DRDC), using PlantForm’s vivoXPRESS® system to produce an antidote to ricin exposure. Ricin, a naturally occurring protein from the castor-bean plant, is extremely toxic to humans when inhaled or injected. PhD9 prevents ricin from penetrating cells.
Recombinant butyrylcholinesterase (rBuChE)
Butyrylcholinesterase (BuChE) is an enzyme that has been developed as a bioscavenger to provide prophylactic protection against nerve agents, such as sarin gas. AntoXa continues to advance the BuChE program begun by its parent company, PlantForm Corporation, under contract with Defence Research and Development Canada.
Hemopexin
Hemopexin is an innovative enzyme drug that shows promise for treating respiratory damage caused by sickle cell disease and exposure to toxic halogens such as chlorine gas. Research by the University of Alabama at Birmingham in collaboration with AntoXa scientists has demonstrated that recombinant human hemopexin, generated in plants using the vivoXPRESS® platform, was equally effective in reversing lung and mitochondrial injury caused by exposure to chlorine gas.