AntoXa and the Government of Canada are co-developing butyrylcholinesterase (BuChE) as a next-generation therapeutic and prophylactic countermeasure to organophosphate toxins such as sarin and soman.
BuChE is a naturally occurring plasma enzyme that provides broad-spectrum protection against all nerve agents. Purified human BChE has been proven efficacious in animal models; however, its development has been limited by relatively low production yield compared to very high cost as well as the inherent risk of human pathogen transmission from the plasma derived product. AntoXa has produced a high-yield, low-cost recombinant BChE using the vivoXPRESS® platform and successfully evaluated the safety of the product in an animal model.
Read more about AntoXa’s product pipeline.