AntoXa

Life-saving biodefense solutions

Antivirals

Antibodies against Ebola

Antibodies produced using the vivoXPRESS® biopharmaceutical manufacturing system have been shown to neutralize the Sudan strain of Ebola as well as antibodies produced using other systems, according to analyses performed by the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID) with funding support and technical advisory services from the National Research Council of Canada Industrial Research Assistance Program (NRC-IRAP).

Building upon the USAMRIID project, our team worked with University of New Mexico scientists to advance Ebola research and improve existing vaccines by inducing more effective immune responses to infection. The project employed the vivoXPRESS® system to express glycoproteins found on Filoviridae, the family of viruses that cause Ebola and Marburg disease, two severe and often fatal viral hemorrhagic fevers that afflict humans and non-human primates.

 

 

Proprietary Technology

Fast, low-cost, versatile and scaleable production

AntoXa holds an exclusive licence to use PlantForm Corporation’s vivoXPRESS® biopharmaceutical manufacturing platform to produce countermeasures for ricin, sarin, soman and the Ebola Sudan virus, as well as other biodefense therapeutics. This tobacco-plant-based system makes it easier, faster and less expensive to produce high-quality biologic drugs for novel indications and new markets.

Key advantages of the vivoXPRESS® platform include:

  • rapid drug development and production timelines
  • high levels of drug expression
  • mammalian-type glycosylation (less risk of unwanted immune reactions)
  • reduced risk profiles versatility (for new product development)
  • unlimited scale-up capability (to respond quickly to increased demand), and
  • manufacturing costs as much as 90 per cent lower than those for mammalian cell technology systems.

Patented next-generation therapeutics

The AntoXa team continues to advance the vivoXPRESS® platform, which originated at the University of Guelph through the work of Dr. J. Christopher Hall. All relevant intellectual property is protected by seven families of patent filings, with three patents issued to date.

Our product pipeline includes innovator antibodies for treatment of ricin exposure as well as the Ebola virus (Sudan strain), and recombinant butyrylcholinesterase (BuChE), an enzyme used as preventative medicine for people vulnerable to attack by nerve agents, organophosphates or other stimulants.

About Us

Plant-made biopharmaceuticals for a safer world. AntoXa Corporation is a Canadian biopharmaceutical company developing medical countermeasures to protect military and civilian personnel from biological and chemical agents that might be used in terrorist attacks, as well as outbreaks of naturally ...
Read more >

Subscribe to our Newsletter

vivoXPRESS® MANUFACTURING SYSTEM
The tobacco-plant-based vivoXPRESS® manufacturing platform offers several advantages over the mammalian and bacterial cell culture systems used to produce most recombinant protein pharmaceuticals. Here’s how it works.

BioPharming Info Centre

Biopharming, also known as plant molecular farming, refers to the use of genetically modified plants to produce a wide range of pharmaceuticals and industrial products. See our Biopharming Info Centre to Learn more about the science and history of using plants to produce complex therapeutic proteins.